Effect of Platelet-Rich Plasma on Episiotomy Wound Healing in Postpartum Women at the Capiatá District Hospital, 2024

Authors

Keywords:

Platelet-Rich Plasma, Episiotomy, Wound Healing, Growth Factors, Postpartum Period

Abstract

Introduction: Episiotomy is a common obstetric procedure and may be associated with complications such as persistent pain, inflammation, infection, and impaired wound healing. Platelet-rich plasma (PRP) is an autologous concentrate containing growth factors that modulate inflammation, stimulate angiogenesis, and accelerate tissue repair, which suggests potential benefits when applied to perineal wounds.

Objective: To compare the effect of PRP on episiotomy wound healing versus natural healing in postpartum women treated at the Hospital Distrital de Capiatá in 2024.

Materials and methods: A descriptive, analytical, and comparative study was conducted with a non-probabilistic sample of 40 postpartum women, divided into two groups: PRP intervention (n = 20) and natural healing (n = 20). PRP was obtained through differential centrifugation and applied along the suture line within the first six hours after delivery. Wound healing was assessed using the Vancouver Scar Scale (VSS) and pain using the Visual Analog Scale (VAS) at 24 hours, 7 days, and 14 days postpartum. Descriptive and inferential statistical analyses were performed.

Results: The PRP group demonstrated a faster and more significant reduction in VSS scores starting on day 7, with substantial improvement by day 14 (2.6 ± 0.9 vs. 5.1 ± 1.1). Pain decreased more rapidly in the intervention group. No adverse reactions related to PRP were observed, whereas the control group presented a slightly higher number of minor complications.

Discussion: PRP promoted faster healing, improved scar quality, and reduced perineal pain compared with natural healing. Its use represents an effective and safe regenerative alternative for managing episiotomy wounds during the immediate postpartum period.

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References

1. Velarde MC, Flynn JM, Day NU, Melov S, Campisi J. Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin. Aging (Albany NY). 2012;4(1):3‐12. https://doi.org/10.18632/aging.100423

2. Eppley BL, Pietrzak WS, Blanton M. Platelet‐rich plasma: a review of biology and applications in plastic surgery. Plast Reconstr Surg. 2006;118(6):147e‐147e. https://doi.org/10.1097/01.prs.0000239606.92676.cf

3. Piipponen M, Li D, Landén NX. The immune functions of keratinocytes in skin wound healing. Int J Mol Sci. 2020; 21(22):8790. https://doi.org/10.3390/ijms21228790

4. Andia I, Abate M. Platelet‐rich plasma: underlying biology and clinical correlates. Regen Med. 2013;8(5):645‐658. https://doi.org/10.2217/rme.13.59

5. Alves R, Grimalt R. A review of platelet‐rich plasma: history, biology, mechanism of action, and classification. Skin Appendage Disord. 2018;4(1):18‐24. https://doi.org/10.1159/000477353

6. Conde Montero E, Fernández Santos ME, Suárez Fernández R. Platelet‐rich plasma: applications in dermatology. Actas Dermosifiliogr. 2015;106(2):104‐111. https://doi.org/10.1016/j.ad.2013.12.021

7. Magruder ML, Caughey S, Gordon AM, Capotosto BSS, Rodeo SA. Trends in utilization, demographics, and costs of platelet‐rich plasma injections: a ten‐year nationwide investigation. Phys Sportsmed. 2024;52(1):89‐97. https://doi.org/10.1080/00913847.2023.2178816

8. Andia I, Rubio‐Azpeitia E, Martin JI, Abate M. Current concepts and translational uses of platelet rich plasma biotechnology. In: Deniz E, ed. Biotechnology. IntechOpen; 2015:Ch. 1. https://scholar.google.com/scholar_lookup?title=Biotechnology&author=I%20Andia&author=E%20Rubio%E2%80%90Azpeitia&author=JI%20Martin&author=M%20Abate&publication_year=2015&

9. Wu CC, Wu YN, HO Ho, Chen KC, Sheu MT, Chiang HS. The neuroprotective effect of platelet‐rich plasma on erectile function in bilateral cavernous nerve injury rat model. J Sex Med. 2012;9(11):2838‐2848. https://doi.org/10.1111/j.1743-6109.2012.02881.x

10. Wu YN, Wu CC, Sheu MT, Chen KC, HO Ho, Chiang HS. Optimization of platelet‐rich plasma and its effects on the recovery of erectile function after bilateral cavernous nerve injury in a rat model. J Tissue Eng Regen Med. 2016;10(10):E294‐E304. https://doi.org/10.1002/term.1806

11. Dankova I, Pyrgidis N, Tishukov M, et al. Efficacy and safety of platelet‐rich plasma injections for the treatment of female sexual dysfunction and stress urinary incontinence: a systematic review. Biomedicines. 2023;11(11):2919. https://doi.org/10.3390/biomedicines11112919

12. Matz EL, Scarberry K, Terlecki R. Platelet‐rich plasma and cellular therapies for sexual medicine and beyond. Sex Med Rev. 2022;10(1):174‐179. https://doi.org/10.1016/j.sxmr.2020.07.001

13. Wang Z, Feng C, Chang G, Liu H, Li S. The use of platelet‐rich plasma in wound healing and vitiligo: a systematic review and meta‐analysis. Skin Res Technol. 2023;29(9):e13444. https://doi.org/10.1111/srt.13444

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Published

2025-12-06

How to Cite

1.
Ortega Martinez E. Effect of Platelet-Rich Plasma on Episiotomy Wound Healing in Postpartum Women at the Capiatá District Hospital, 2024. Cienc. Est. [Internet]. 2025 Dec. 6 [cited 2026 May 24];1(3):64-70. Available from: https://cienciayestetica.org/index.php/revista/article/view/13

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Vol. 1 No. 3 (2025): Septiembre - Diciembre

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Artículos originales

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Copyright (c) 2025 Edith Ortega Martinez

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