Clinical Experience in Cases of Combined Penile Application of Botulinum Toxin Type A and Platelet-Rich Plasma
A Preliminary Observational Study
Keywords:
Botulinum Toxins, Type A, Platelet-Rich Plasma, Penis, Sexual FunctionAbstract
Introduction: The combined penile application of botulinum toxin type A (BTX-A) and platelet-rich plasma (PRP) has gained interest as a minimally invasive strategy to improve functional and aesthetic aspects of male sexual health. Scientific evidence remains limited, particularly regarding combined treatments.
Objective: To describe the safety, tolerability, and preliminary clinical outcomes of penile BTX-A + PRP application in adult patients.
Materials and methods: A prospective observational study was conducted including 15 men aged 25–58 years. Patients received BTX-A (10–20 U) injected into the dartos muscle and PRP (3–5 mL) infiltrated into the superficial penile plane. Outcomes assessed at 4 and 12 weeks included adverse effects, pain, perceived rigidity, erotic sensitivity, penile aesthetics, and overall satisfaction.
Results: The procedure demonstrated a favorable safety profile with no severe complications. Post-procedural pain was mild (VAS 2/10). At 12 weeks, 73.3% reported improved rigidity, 66.7% increased erotic sensitivity, and 80% improved skin quality. Overall satisfaction reached 86.7%. Adverse events were mild and transient (edema, mild bruising, temporary hypersensitivity).
Discussion: Combined BTX-A and PRP penile application appears to be safe, well tolerated, and associated with subjective improvements in functional and aesthetic parameters. These preliminary findings support its potential as a therapeutic option in male aesthetic and sexual medicine. Controlled studies with larger samples are warranted.
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